Effect of Disease Activity, Glucocorticoid Exposure, and Rituximab on Body Composition During Induction Treatment of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

ABSTRACT:

Objective

We investigated the relationships between glucocorticoid use, disease activity, and changes in body mass index (BMI) in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV).

Methods

We analyzed AAV patients enrolled in the Rituximab in AAV trial. Glucocorticoid use, BMI, and disease activity were measured regularly during the trial period. We performed mixed-effects regressions to examine the associations of time-dependent cumulative average glucocorticoid use and disease activity with changes in BMI over time, while adjusting for potential confounders.

Results

The mean ± SD baseline BMI of the 197 patients enrolled was 28.8 ± 6.3 kg/m² . Patients with newly diagnosed AAV tended to have a lower mean ± SD BMI than those wit

SUBMITTER: Wallace ZS 

PROVIDER: S-EPMC5611860 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature