Circulating complement factor H-related proteins 1 and 5 correlate with disease activity in IgA nephropathy.

ABSTRACT: IgA nephropathy (IgAN) is a common cause of chronic kidney disease and end-stage renal failure, especially in young people. Due to a wide range of clinical outcomes and difficulty in predicting response to immunosuppression, we need to understand why and identify which patients with IgAN will develop progressive renal impairment. A deletion polymorphism affecting the genes encoding the complement factor H-related protein (FHR)-1 and FHR-3 is robustly associated with protection against IgAN. Some FHR proteins, including FHR-1 and FHR-5, antagonize the ability of complement factor H (fH), the major negative regulator of the complement alternative pathway, to inhibit complement activation on surfaces, a process termed fH deregulation. From a large cohort of patients, we demonstrated that plas

SUBMITTER: Medjeral-Thomas NR 

PROVIDER: S-EPMC5611987 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature