A sweet development in Notch regulation.

ABSTRACT: The transmembrane signaling protein Notch, which is crucial for embryonic cell fate decisions, has 36 extracellular EGF domains that are glycosylated in variable and complex ways. A new study shows that O-fucose and O-glucose stabilize the repeats but that extension of glucose by xylose weakens stability, explained by the binding of the glycan to a protein groove. This work shows how different types of glycosylation can distinctly influence protein stability and structure.

SUBMITTER: Bakker H 

PROVIDER: S-EPMC5612126 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature