The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.

ABSTRACT: Sharpin, a multifunctional adaptor protein, regulates several signalling pathways. For example, Sharpin enhances signal-induced NF-κB signalling as part of the linear ubiquitin assembly complex (LUBAC) and inhibits integrins, the T cell receptor, caspase 1 and PTEN. However, despite recent insights into Sharpin and LUBAC function, a systematic approach to identify the signalling pathways regulated by Sharpin has not been reported. Here, we present the first 'Sharpin interactome', which identifies a large number of novel potential Sharpin interactors in addition to several known ones. These data suggest that Sharpin and LUBAC might regulate a larger number of biological processes than previously identified, such as endosomal trafficking, RNA processing, metabolism and cytoskeleton regulatio

SUBMITTER: Khan MH 

PROVIDER: S-EPMC5612173 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature