An autophagy-driven pathway of ATP secretion supports the aggressive phenotype of BRAF^V600E inhibitor-resistant metastatic melanoma cells.

ABSTRACT: The ingrained capacity of melanoma cells to rapidly evolve toward an aggressive phenotype is manifested by their increased ability to develop drug-resistance, evident in the case of vemurafenib, a therapeutic-agent targeting BRAF^V600E. Previous studies indicated a tight correlation between heightened melanoma-associated macroautophagy/autophagy and acquired Vemurafenib resistance. However, how this vesicular trafficking pathway supports Vemurafenib resistance remains unclear. Here, using isogenic human and murine melanoma cell lines of Vemurafenib-resistant and patient-derived melanoma cells with primary resistance to the BRAF^V600E inhibitor, we found that the enhanced migration and invasion of the resistant melanoma cells correlated with an enhanced autophagic capaci

SUBMITTER: Martin S 

PROVIDER: S-EPMC5612289 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature