Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web.

ABSTRACT: We demonstrate the usage of Bio3D-web for the interactive analysis of biomolecular structure data. The Bio3D-web application provides online functionality for: (1) The identification of related protein structure sets to user specified thresholds of similarity; (2) Their multiple alignment and structure superposition; (3) Sequence and structure conservation analysis; (4) Inter-conformer relationship mapping with principal component analysis, and (5) comparison of predicted internal dynamics via ensemble normal mode analysis. This integrated functionality provides a complete online workflow for investigating sequence-structure-dynamic relationships within protein families and superfamilies.

SUBMITTER: Jariwala S 

PROVIDER: S-EPMC5612356 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature