CYP2B6 genotypes and early efavirenz-based HIV treatment outcomes in Botswana.

ABSTRACT:

Objectives

To determine the association between cytochrome p450 2B6 genotypes and efavirenz-based HIV treatment outcomes.

Design

Observational cohort study of HIV-infected adults initiating efavirenz-based regimens in Botswana.

Methods

The primary endpoint was a composite of death or loss to care or HIV RNA more than 25 copies/ml at 6 months. CYP2B6 516G>T and 983T>C genotyping was done with Taqman Open Array platform. Adverse experiences were measured by using the Subject Experience Questionnaire. Metabolism alleles were included in logistic regression models of the composite endpoint.

Results

A total of 801 individuals included 406 (51%) men, median age 37 years, median baseline CD4 cell count 195 cells/μl, and plasma HIV RNA 4.9 log10 copies/ml. 288 (36%) re

SUBMITTER: Gross R 

PROVIDER: S-EPMC5612381 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature