Maternal exposure to ozone and PM_2.5 and the prevalence of orofacial clefts in four U.S. states.

ABSTRACT:

Background

While there is some evidence that maternal exposure to ambient air pollution is associated with orofacial clefts in offspring, the epidemiologic studies have been largely equivocal. We evaluated whether maternal exposure to elevated county-level ambient fine particulate matter with aerodynamic diameter ≤2.5µm (PM_2.5) and ozone during early gestation was associated with a higher prevalence of orofacial clefts.

Methods

Birth data consisting of 4.7 million births from 2001 to 2007 were obtained from National Birth Defects Prevention Network for four states - Arizona, Florida, New York (excluding New York City), and Texas. The air pollution exposure assessment for gestational weeks 5-10 was based on county-level average concentrations of PM_2.5 an

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC5612445 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature