Cryptogenic organizing pneumonia-Results of treatment with clarithromycin versus corticosteroids-Observational study.

ABSTRACT:

Background

Cryptogenic organizing pneumonia (COP) is a clinicopathological syndrome of unknown origin. Corticosteroids are the standard treatment, but clarithromycin (CAM) is also effective. The aim of this observational retrospective study was to compare the results of CAM versus prednisone (PRE) treatment in patients with biopsy-proven OP without respiratory insufficiency.

Material and methods

In a 15-year period, 40 patients were treated with CAM (500 mg twice daily orally for 3 months) and 22 with PRE (mean initial dose of 0.67 ± 0.24 mg/kg/d for a mean of 8.59 ± 3.05 months).

Results

The clinical presentation, laboratory, and radiological findings did not differ markedly between patients treated with CAM and PRE, with the exception of a higher frequency of sweats

SUBMITTER: Radzikowska E 

PROVIDER: S-EPMC5612459 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature