Analysis of immunological mechanisms exerted by HBsAg-HBIG therapeutic vaccine combined with Adefovir in chronic hepatitis B patients.

ABSTRACT: An HBsAg-HBIG therapeutic vaccine (Yeast-derived Immune Complexes, YIC) for chronic hepatitis B (CHB) patients has undergone a series of clinical trials. The HBeAg sero-conversion rate of YIC varied from 21.9% to 14% depending on the immunization protocols from 6 to 12 injections. To analyze the immunological mechanisms exerted by 6 injections of YIC, 44 CHB patients were separately immunized with YIC, alum as adjuvant control or normal saline as blank control, with add on of antiviral drug Adefovir in all groups. Kinetic increase in Th1 and Th2 cells CD4⁺ T cell sub-populations with association in decrease in Treg cells and increase of Tc1 and Tc17 cells in CD8⁺ T cells were observed in YIC immunized group. No such changes were found in the other groups. By multifunc

SUBMITTER: Zhou C 

PROVIDER: S-EPMC5612521 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature