Radiogenomics of neuroblastomas: Relationships between imaging phenotypes, tumor genomic profile and survival.

ABSTRACT:

Purpose

This study investigated relationships between neuroblastomas (NBs) imaging phenotypes, tumor genomic profile and patient outcome.

Patients and methods

This IRB-approved retrospective observational study included 133 NB patients (73 M, 60 F; median age 15 months, range 0-151) treated in a single institution between 1998 and 2012. A consensus review of imaging (CT-scan, MRI) categorized tumors according to both the primarily involved compartment (i.e., neck, chest, abdomen or pelvis) and the sympathetic anatomical structure the tumors rose from (i.e., cervical, paravertebral or periarterial chains, or adrenal gland). Tumor shape, volume and image-defined surgical risk factors (IDRFs) at diagnosis were recorded. Genomic profiles were assessed using array-based comparati

SUBMITTER: Brisse HJ 

PROVIDER: S-EPMC5612658 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature