The association between DNA methylation and exon expression in the Pacific oyster Crassostrea gigas.

ABSTRACT:

Background

DNA methylation is one of the most important epigenetic modifications of eukaryotic genomes and is believed to play integral roles in diverse biological processes. Although DNA methylation has been well studied in mammals, data are limited in invertebrates, particularly Mollusca. The Pacific oyster Crassostrea gigas is an emerging genetic model for functional analysis of DNA methylation in Mollusca. Recent studies have shown that there is a positive association between methylation status and gene expression in C. gigas; however, whether this association exists at the exon level remains to be determined.

Results

In this study, we characterized the genome-wide methylation pattern across two different tissues of C. gigas and found that methylated genes are expressed

SUBMITTER: Song K 

PROVIDER: S-EPMC5612690 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature