Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma.

ABSTRACT:

Background

Alveolar soft part sarcoma (ASPS) is an extremely rare metastatic soft tissue tumor with a poor prognosis for which no effective systemic therapies have yet been established. Therefore, the development of novel effective treatment approaches is required. Tyrosine kinases (TKs) are being increasingly used as therapeutic targets in a variety of cancers. The purpose of this study was to identify novel therapeutic target TKs and to clarify the efficacy of TK inhibitors (TKIs) in the treatment of ASPS.

Experimental design

To identify novel therapeutic target TKs in ASPS, we evaluated the antitumor effects and kinase activity of three TKIs (pazopanib, dasatinib, and cabozantinib) against ASPS cells using an in vitro assay. Based on these results, we then investigated th

SUBMITTER: Mukaihara K 

PROVIDER: S-EPMC5612696 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature