Loss of Cardioprotective Effects at the <i>ADAMTS7</i> Locus as a Result of Gene-Smoking Interactions.

ABSTRACT:

Background

Common diseases such as coronary heart disease (CHD) are complex in etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent role. However, gene-lifestyle interactions for CHD have been difficult to identify. Here, we investigate interaction of smoking behavior, a potent lifestyle factor, with genotypes that have been shown to associate with CHD risk.

Methods

We analyzed data on 60 919 CHD cases and 80 243 controls from 29 studies for gene-smoking interactions for genetic variants at 45 loci previously reported to be associated with CHD risk. We also studied 5 loci associated with smoking behavior. Study-specific gene-smoking interaction effects were calculated and pooled using fixed-effects meta-analyses. Interaction analyse

SUBMITTER: Saleheen D 

PROVIDER: S-EPMC5612779 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature