Parenteral irons versus transfused red blood cells for treatment of anemia during canine experimental bacterial pneumonia.

ABSTRACT:

Background

No studies have been performed comparing intravenous (IV) iron with transfused red blood cells (RBCs) for treating anemia during infection. In a previous report, transfused older RBCs increased free iron release and mortality in infected animals when compared to fresher cells. We hypothesized that treating anemia during infection with transfused fresh RBCs, with minimal free iron release, would prove superior to IV iron therapy.

Study design and methods

Purpose-bred beagles (n = 42) with experimental Staphylococcus aureus pneumonia rendered anemic were randomized to be transfused RBCs stored for 7 days or one of two IV iron preparations (7 mg/kg), iron sucrose, a widely used preparation, or ferumoxytol, a newer formulation that blunts circulating iron levels.

R

SUBMITTER: Suffredini DA 

PROVIDER: S-EPMC5612854 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature