Relationship between the omega-3 index and specialized pro-resolving lipid mediators in patients with peripheral arterial disease taking fish oil supplements.

ABSTRACT:

Background

Oral supplementation with n-3 polyunsaturated fatty acids (PUFA) increases the omega-3 index, a biomarker of red blood cell eicosapentaenoic acid and docosahexaenoic acid, and plasma levels of biosynthesis pathway markers and potent lipid mediators involved in the resolution of inflammation among patients with peripheral arterial disease (PAD).

Objective

We aimed to quantify the association between an upstream change in the omega-3 index and downstream changes in lipid mediator production.

Methods

We conducted a secondary analysis of the OMEGA-PAD I Trial, a randomized, placebo controlled trial investigating high-dose n-3 PUFA oral supplementation in PAD patients. Eighty subjects were randomized to either 4.4 g of fish oil or placebo for 1 month. Regression

SUBMITTER: Schaller MS 

PROVIDER: S-EPMC5612881 | biostudies-literature | 2017 Sep - Oct

REPOSITORIES: biostudies-literature