Effects of β-blockers on house dust mite-driven murine models pre- and post-development of an asthma phenotype.

ABSTRACT:

Background

Our previous studies suggested certain β-adrenoceptor blockers (β-blockers) attenuate the asthma phenotype in ovalbumin driven murine models of asthma. However, the ovalbumin model has been criticized for lack of clinical relevance.

Methods

We tested the non-selective β-blockers, carvedilol and nadolol, in house dust mite (HDM) driven murine asthma models where drugs were administered both pre- and post-development of the asthma phenotype. We measured inflammation, mucous metaplasia, and airway hyper-responsiveness (AHR). We also measured the effects of the β-blockers on extracellular-signal regulated kinase (ERK 1/2) phosphorylation in lung homogenates.

Results

We show that nadolol, but not carvedilol, attenuated inflammation and mucous metaplasia, and had

SUBMITTER: Joshi R 

PROVIDER: S-EPMC5612908 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature