Decreased surface expression of the δ subunit of the GABA_A receptor contributes to reduced tonic inhibition in dentate granule cells in a mouse model of fragile X syndrome.

ABSTRACT: While numerous changes in the GABA system have been identified in models of Fragile X Syndrome (FXS), alterations in subunits of the GABA_A receptors (GABA_ARs) that mediate tonic inhibition are particularly intriguing. Considering the key role of tonic inhibition in controlling neuronal excitability, reduced tonic inhibition could contribute to FXS-associated disorders such as hyperactivity, hypersensitivity, and increased seizure susceptibility. The current study has focused on the expression and function of the δ subunit of the GABA_AR, a major subunit involved in tonic inhibition, in granule cells of the dentate gyrus in the Fmr1 knockout (KO) mouse model of FXS. Electrophysiological studies of dentate granule cells revealed a marked, nearly four-fold, dec

SUBMITTER: Zhang N 

PROVIDER: S-EPMC5612918 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature