Early treatment with tolvaptan improves diuretic response in acute heart failure with renal dysfunction.

ABSTRACT:

Background

Poor response to diuretics is associated with worse prognosis in patients with acute heart failure (AHF). We hypothesized that treatment with tolvaptan improves diuretic response in patients with AHF.

Methods

We performed a secondary analysis of the AQUAMARINE open-label randomized study in which a total of 217 AHF patients with renal impairment (eGFR < 60 mL/min/1.73 m²) were randomized to either tolvaptan or conventional treatment. We evaluated diuretic response to 40 mg furosemide or its equivalent based on two different parameters: change in body weight and net fluid loss within 48 h.

Results

The mean time from patient presentation to randomization was 2.9 h. Patients with a better diuretic response showed greater relief of dyspnea and less w

SUBMITTER: Matsue Y 

PROVIDER: S-EPMC5613036 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature