Functional IGF1R variant predicts breast cancer risk in women with preeclampsia in California Teachers Study.

ABSTRACT:

Purpose

Hypertension in pregnancy has been associated with decreased future risk of breast cancer in many but not all studies. In the Marin Women's Study, pregnancy-induced hypertension was shown to interact with the T allele of a functional IGF1R gene variant, rs2016347, to result in lower breast density, as well as decreased breast cancer risk. Our objective was to explore these findings in a larger sample of women from the California Teachers Study (CTS).

Methods

The CTS cohort consists of over 130,000 female educators. DNA was available from a nested case-control study, which included 2,030 non-Hispanic white women who developed breast cancer and 1,552 controls. The current study included all participants from the case-control group with a self-reported history of preecl

SUBMITTER: Powell MJ 

PROVIDER: S-EPMC5613056 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature