Immunological Changes in Blood of Newborns Exposed to Anti-TNF-α during Pregnancy.

ABSTRACT:

Background

Although anti-TNF-α monoclonal antibodies are considered safe during pregnancy, there are no studies on the development of the exposed-infant immune system. The objective was to study for the first time the impact of throughout pregnancy exposure to anti-TNF-α has an impact in the development of the infant's immune system, especially B cells and the IL-12/IFN-γ pathway.

Methods

Prospective study of infants born to mothers with inflammatory bowel disease treated throughout pregnancy with anti-TNF-α (adalimumab/infliximab). Infants were monitored both clinically and immunologically at birth and at 3, 6, 12, and 18 months.

Results

We included seven patients and eight healthy controls. Exposed infants had detectable levels of anti-TNF-α until 6 months of age; t

SUBMITTER: Esteve-Sole A 

PROVIDER: S-EPMC5613099 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature