Ontology highlight
ABSTRACT:
SUBMITTER: Ivanova I
PROVIDER: S-EPMC5613143 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Ivanova Ivayla I Much Christian C Di Giacomo Monica M Azzi Chiara C Morgan Marcos M Moreira Pedro N PN Monahan Jack J Carrieri Claudia C Enright Anton J AJ O'Carroll Dónal D
Molecular cell 20170831 6
YTHDF2 binds and destabilizes N<sup>6</sup>-methyladenosine (m<sup>6</sup>A)-modified mRNA. The extent to which this branch of m<sup>6</sup>A RNA-regulatory pathway functions in vivo and contributes to mammalian development remains unknown. Here we find that YTHDF2 deficiency is partially permissive in mice and results in female-specific infertility. Using conditional mutagenesis, we demonstrate that YTHDF2 is autonomously required within the germline to produce MII oocytes that are competent to ...[more]