The Serotonin Receptor Subtype 5b Specifically Interacts with Serotonin Receptor Subtype 1A.

ABSTRACT: Previously, we described the dysregulation of serotonin (5-HT) receptor subtype 5b (5-ht_5b) in a mouse model of Rett syndrome (RTT). 5-ht_5b has not been extensively studied, so we set out to characterize it in more detail. Unlike common cell surface receptors, 5-ht_5b displays no membrane expression, while receptor clusters are located in endosomes. This unusual subcellular localization is at least in part controlled by glycosylation of the N-terminus, with 5-ht_5b possessing fewer glycosylation sites than related receptors. We analyzed whether the localization to endosomes has any functional relevance and found that 5-ht_5b receptors can specifically interact with 5-HT_1A receptors and retain them in endosomal compartments. Thi

SUBMITTER: Niebert S 

PROVIDER: S-EPMC5613149 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature