Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.

ABSTRACT: More than 20 genetic loci have been associated with risk for Alzheimer's disease (AD), but reported genome-wide significant loci do not account for all the estimated heritability and provide little information about underlying biological mechanisms. Genetic studies using intermediate quantitative traits such as biomarkers, or endophenotypes, benefit from increased statistical power to identify variants that may not pass the stringent multiple test correction in case-control studies. Endophenotypes also contain additional information helpful for identifying variants and genes associated with other aspects of disease, such as rate of progression or onset, and provide context to interpret the results from genome-wide association studies (GWAS). We conducted GWAS of amyloid beta (Aβ₄₂

SUBMITTER: Deming Y 

PROVIDER: S-EPMC5613285 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature