INRA, a new high-frequency antigen in the INDIAN (IN023) blood group system.

ABSTRACT:

Background

The INDIAN blood group system comprises 4 antigens sensitive to enzymes and 2-aminoethyl isothiouronium bromide (AET).

Aim

The patient's antibody was investigated for its specificity to the high-frequency antigens (HFA) of this system.

Material and methods

Low ionic strength solution (LISS)-tube/LISS-indirect antiglobulin test (IAT) methods were used. The patient's red blood cells (RBCs) were tested with antisera to HFA. Her antibody was tested with RBCs lacking the HFA. Furthermore, it was tested with RBCs as untreated or treated with enzyme or AET. The genetic sequence was studied for mutation in CD44 gene that encodes INDIAN antigens.

Results

The patient was grouped A1B, RhD+, antibody screening test positive, direct antiglobulin test negat

SUBMITTER: Joshi SR 

PROVIDER: S-EPMC5613417 | biostudies-literature | 2017 Jul-Dec

REPOSITORIES: biostudies-literature