HIV viral kinetics and T cell dynamics in antiretroviral naive persons starting an integrase strand transfer inhibitor and protease inhibitor regimen.

ABSTRACT:

Background

Nucleos(t)ide reverse transcriptase inhibitor (NRTI)-sparing regimens may potentially minimize antiretroviral (ART) toxicities, but demonstrate mixed efficacy and toxicity results. The impact of an integrase strand transfer inhibitor (INSTI) and protease inhibitor (PI) regimen on HIV viral dynamics and T cell kinetics remains underdescribed.

Objective

To compare the effect of raltegravir + ritonavir boosted lopinavir (RAL + LPV/r) to efavirenz/tenofovir disoproxil fumarate/emtricitabine (EFV/TDF/FTC) on HIV kinetics and T cell dynamics.

Methods

Fifty participants naïve to ART underwent HIV viral kinetic sampling evaluated using biexponential mixed effects modeling. A subset of 28 subjects (with complete viral suppression) underwent flow cytometry and evalua

SUBMITTER: Karris MY 

PROVIDER: S-EPMC5613656 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature