Murine model of hepatic breast cancer.
Ontology highlight
ABSTRACT: Background and aims
Breast cancer is the most common cancer in women and the second leading cause of cancer-related deaths in this population. Breast cancer related deaths have declined due to screening and adjuvant therapies, yet a driving clinical need exists to better understand the cause of the deadliest aspect of breast cancer, metastatic disease. Breast cancer metastasizes to several distant organs, the liver being the third most common site. To date, very few murine models of hepatic breast cancer exist.Methods
In this study, a novel murine model of liver breast cancer using the MDA-MB-231 cell line is introduced as an experimental (preclinical) model.Results
Histological typing revealed consistent hepatic breast cancer tumor foci. Common features of the murine model were vascular invasion, lung metastasis and peritoneal seeding.Conclusions
The novel murine model of hepatic breast cancer established in this study provides a tool to be used to investigate mechanisms of hepatic metastasis and to test potential therapeutic interventions.
SUBMITTER: Rikhi R
PROVIDER: S-EPMC5613703 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Murine model of hepatic breast cancer.
Rikhi Rishi R Wilson Elizabeth M EM Deas Olivier O Svalina Matthew N MN Bial John J Mansoor Atiya A Cairo Stefano S Keller Charles C
Biochemistry and biophysics reports 20160804
<h4>Background and aims</h4>Breast cancer is the most common cancer in women and the second leading cause of cancer-related deaths in this population. Breast cancer related deaths have declined due to screening and adjuvant therapies, yet a driving clinical need exists to better understand the cause of the deadliest aspect of breast cancer, metastatic disease. Breast cancer metastasizes to several distant organs, the liver being the third most common site. To date, very few murine models of hepa ...[more]
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