Murine model of hepatic breast cancer.

ABSTRACT:

Background and aims

Breast cancer is the most common cancer in women and the second leading cause of cancer-related deaths in this population. Breast cancer related deaths have declined due to screening and adjuvant therapies, yet a driving clinical need exists to better understand the cause of the deadliest aspect of breast cancer, metastatic disease. Breast cancer metastasizes to several distant organs, the liver being the third most common site. To date, very few murine models of hepatic breast cancer exist.

Methods

In this study, a novel murine model of liver breast cancer using the MDA-MB-231 cell line is introduced as an experimental (preclinical) model.

Results

Histological typing revealed consistent hepatic breast cancer tumor foci. Common features of the muri

SUBMITTER: Rikhi R 

PROVIDER: S-EPMC5613703 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature