Modulating Wnt Signaling Rescues Palate Morphogenesis in Pax9 Mutant Mice.

ABSTRACT: Cleft palate is a common birth defect caused by disruption of palatogenesis during embryonic development. Although mutations disrupting components of the Wnt signaling pathway have been associated with cleft lip and palate in humans and mice, the mechanisms involving canonical Wnt signaling and its regulation in secondary palate development are not well understood. Here, we report that canonical Wnt signaling plays an important role in Pax9-mediated regulation of secondary palate development. We found that cleft palate pathogenesis in Pax9-deficient embryos is accompanied by significantly reduced expression of Axin2, an endogenous target of canonical Wnt signaling, in the developing palatal mesenchyme, particularly in the posterior regions of the palatal shelves. We found that expression o

SUBMITTER: Li C 

PROVIDER: S-EPMC5613879 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature