Topoisomerase expression and amplification in solid tumours: Analysis of 24,262 patients.

ABSTRACT:

Background

Topoisomerase I (TOPO1) and topoisomerase IIα (TOP2A) are specific targets of multiple chemotherapy drugs. Increased expression of TOPO1 protein and amplification of the TOP2A gene have been associated with treatment response in colorectal and breast cancers, respectively. TOPO1 and TOP2A may be potential therapeutic targets in other malignancies as well.

Summary of methods

We analysed TOPO1 protein expression and TOP2A gene amplification in patients (n = 24,262 specimens) with diverse cancers. Since HER2 and TOP2A co-amplification have been investigated for predictive value regarding anthracycline benefit, we analysed specimens for HER2 amplification as well.

Results

Overexpressed TOPO1 protein was present in 51% of the tumours. Four percent of the tumours

SUBMITTER: Heestand GM 

PROVIDER: S-EPMC5613945 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature