Rapid Screening of Primary Aldosteronism by a Novel Chemiluminescent Immunoassay.

ABSTRACT: Measurement of plasma aldosterone and renin concentration, or activity, is useful for selecting antihypertensive agents and detecting hyperaldosteronism in hypertensive patients. However, it takes several days to get results when measured by radioimmunoassay and development of more rapid assays has been long expected. We have developed chemiluminescent enzyme immunoassays enabling the simultaneous measurement of both aldosterone and renin concentrations in 10 minutes by a fully automated assay using antibody-immobilized magnetic particles with quick aggregation and dispersion. We performed clinical validation of diagnostic ability of this newly developed assay-based screening of 125 patients with primary aldosteronism from 97 patients with essential hypertension. Results of this novel assa

SUBMITTER: Morimoto R 

PROVIDER: S-EPMC5613948 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature