Interpolating and extrapolating with hmsIST: seeking a t_max for optimal sensitivity, resolution and frequency accuracy.

ABSTRACT: Non-Uniform Sampling has the potential to exploit the optimal resolution of high-field NMR instruments. This is not possible in 3D and 4D NMR experiments when using traditional uniform sampling due to the long overall measurement time. Nominally, uniformly sampled time domain data acquired to a maximum evolution time t_max can be extended to high resolution via a virtual maximum evolution time t*_max while extrapolating with linear prediction or iterative soft thresholding (IST). At the high resolution obtainable with extrapolation of US data, however, the accuracy of peak positions is compromised as observed when comparing inter- and intra-residue peaks in a 3D HNCA experiment. However, the accuracy of peak positions is largely improved by spreading the same number of

SUBMITTER: Hyberts SG 

PROVIDER: S-EPMC5614452 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature