Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.

ABSTRACT: Our understanding of endocytosis has evolved remarkably in little more than a decade. This is the result not only of advances in our knowledge of its molecular and biological workings, but also of a true paradigm shift in our understanding of what really constitutes endocytosis and of its role in homeostasis. Although endocytosis was initially discovered and studied as a relatively simple process to transport molecules across the plasma membrane, it was subsequently found to be inextricably linked with almost all aspects of cellular signaling. This led to the notion that endocytosis is actually the master organizer of cellular signaling, providing the cell with understandable messages that have been resolved in space and time. In essence, endocytosis provides the communications and supply

SUBMITTER: Sigismund S 

PROVIDER: S-EPMC5614474 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature