A relation between osteoclastogenesis inhibition and membrane-type estrogen receptor GPR30.

ABSTRACT: Disruption of the cooperative balance between osteoblasts and osteoclasts causes various bone disorders, some of which are because of abnormal osteoclast recruitment. Osteoporosis, one of the bone disorders, is not effectively treated by currently available medicines. In addition to the development of novel drugs for palliative treatment, the exploitation of novel compounds for preventive treatment is important in an aging society. Quercetin, a major flavonoid found in many fruits and vegetables, has been expected to inhibit cancer and prevent several diseases because of its anti-inflammatory and estrogenic functions. It has been reported that quercetin has the potential to reduce bone resorption, but the mechanism by which this compound affects the differentiation of osteoclasts remains u

SUBMITTER: Masuhara M 

PROVIDER: S-EPMC5614543 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature