The para isomer of dinitrobenzene disrupts redox homeostasis in liver and kidney of male wistar rats.

ABSTRACT:

Background

Para-Dinitrobenzene (p-DNB) is one of the isomers of dinitrobenzene which have been detected as environmental toxicants. Skin irritation and organ toxicities are likely for industrial workers exposed to p-DNB. This study evaluated the effect of sub-chronic exposure of rats to p-DNB on cellular redox balance, hepatic and renal integrity.

Methods

Forty eight male Wistar rats weighing 160-180 g were administered 50, 75, 1000 and 2000 mg/kg b.wt (body weight) of p-DNB or an equivalent volume of vehicle (control) orally and topically for 14 days. After the period of treatment, the activities of kidney and liver catalase (CAT), alkaline phosphatase (ALP) and superoxide dismutase (SOD) as well as extent of renal and hepatic lipid peroxi

SUBMITTER: Sangodele JO 

PROVIDER: S-EPMC5614678 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature