Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.

ABSTRACT:

Background

Degradation of white matter microstructure has been demonstrated in frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). In preparation for clinical trials, ongoing studies are investigating the utility of longitudinal brain imaging for quantification of disease progression. To date only one study has examined sample size calculations based on longitudinal changes in white matter integrity in FTLD.

Objective

To quantify longitudinal changes in white matter microstructural integrity in the three canonical subtypes of frontotemporal dementia (FTD) and AD using diffusion tensor imaging (DTI).

Methods

60 patients with clinical diagnoses of FTD, including 27 with behavioral variant frontotemporal dementia (bvFTD), 14 with non-fluent variant pri

SUBMITTER: Elahi FM 

PROVIDER: S-EPMC5614750 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature