Cerebellar granule cell replenishment postinjury by adaptive reprogramming of Nestin⁺ progenitors.

ABSTRACT: Regeneration of several organs involves adaptive reprogramming of progenitors, but the intrinsic capacity of the developing brain to replenish lost cells remains largely unknown. Here we found that the developing cerebellum has unappreciated progenitor plasticity, since it undergoes near full growth and functional recovery following acute depletion of granule cells, the most plentiful neuron population in the brain. We demonstrate that following postnatal ablation of granule cell progenitors, Nestin-expressing progenitors, specified during mid-embryogenesis to produce astroglia and interneurons, switch their fate and generate granule neurons in mice. Moreover, Hedgehog signaling in two Nestin-expressing progenitor populations is crucial not only for the compensatory replenishment of granul

SUBMITTER: Wojcinski A 

PROVIDER: S-EPMC5614835 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature