Parvovirus B19 Infection in Children With Arterial Ischemic Stroke.

ABSTRACT:

Background and purpose

Case-control studies suggest that acute infection transiently increases the risk of childhood arterial ischemic stroke. We hypothesized that an unbiased pathogen discovery approach utilizing MassTag-polymerase chain reaction would identify pathogens in the blood of childhood arterial ischemic stroke cases.

Methods

The multicenter international VIPS study (Vascular Effects of Infection in Pediatric Stroke) enrolled arterial ischemic stroke cases, and stroke-free controls, aged 29 days through 18 years. Parental interview included questions on recent infections. In this pilot study, we used MassTag-polymerase chain reaction to test the plasma of the first 161 cases and 34 controls enrolled for a panel of 28 common bacterial and viral pathogens.

Result

SUBMITTER: Fullerton HJ 

PROVIDER: S-EPMC5614850 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature