Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk.

ABSTRACT: A capability for analyzing complex cellular communication among tissues is important in drug discovery and development, and in vitro technologies for doing so are required for human applications. A prominent instance is communication between the gut and the liver, whereby perturbations of one tissue can influence behavior of the other. Here, we present a study on human gut-liver tissue interactions under normal and inflammatory contexts, via an integrative multi-organ platform comprising human liver (hepatocytes and Kupffer cells), and intestinal (enterocytes, goblet cells, and dendritic cells) models. Our results demonstrated long-term (>2 weeks) maintenance of intestinal (e.g., barrier integrity) and hepatic (e.g., albumin) functions in baseline interaction. Gene expression data comparin

SUBMITTER: Chen WLK 

PROVIDER: S-EPMC5614865 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature