IFN-γ-STAT1-iNOS Induces Myeloid Progenitors to Acquire Immunosuppressive Activity.

ABSTRACT: Autoimmune diseases often induce dysregulated hematopoiesis with altered number and function of hematopoietic stem and progenitor cells (HSPCs). However, there are limited studies on the direct regulation of HSPCs on T cells, which are often detrimental to autoimmunity. Here, we found that in a murine model of Concanavalin A-induced autoimmune hepatitis, LSK (Lineage^-Sca-1⁺c-Kit⁺)-like cells accumulated in liver, spleen, and bone marrow (BM), which were myeloid progenitors (Lineage^-Sca-1^-c-Kit⁺) that upregulated Sca-1 expression upon T cell-derived IFN-γ stimulation. Strikingly, BM LSK-like cells from mice induced by Con A to develop autoimmune hepatitis or alternatively myeloid progenitors from wild-type mice possessed stro

SUBMITTER: Yang SH 

PROVIDER: S-EPMC5614959 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature