Transcriptomic Signatures of Tacaribe Virus-Infected Jamaican Fruit Bats.

ABSTRACT: Tacaribe virus (TCRV) is a mammalian arenavirus that was first isolated from artibeus bats in the 1950s. Subsequent experimental infection of Jamaican fruit bats (Artibeus jamaicensis) caused a disease similar to that of naturally infected bats. Although substantial attention has focused on bats as reservoir hosts of viruses that cause human disease, little is known about the interactions between bats and their pathogens. We performed a transcriptome-wide study to illuminate the response of Jamaican fruit bats experimentally infected with TCRV. Differential gene expression analysis of multiple tissues revealed global and organ-specific responses associated with innate antiviral responses, including interferon alpha/beta and Toll-like receptor signaling, activation of complement casc

SUBMITTER: Gerrard DL 

PROVIDER: S-EPMC5615131 | biostudies-literature | 2017 Sep-Oct

REPOSITORIES: biostudies-literature