The Gut Microbiota of Healthy Aged Chinese Is Similar to That of the Healthy Young.

ABSTRACT: The microbiota of the aged is variously described as being more or less diverse than that of younger cohorts, but the comparison groups used and the definitions of the aged population differ between experiments. The differences are often described by null hypothesis statistical tests, which are notoriously irreproducible when dealing with large multivariate samples. We collected and examined the gut microbiota of a cross-sectional cohort of more than 1,000 very healthy Chinese individuals who spanned ages from 3 to over 100 years. The analysis of 16S rRNA gene sequencing results used a compositional data analysis paradigm coupled with measures of effect size, where ordination, differential abundance, and correlation can be explored and analyzed in a unified and reproducible framework. Our

SUBMITTER: Bian G 

PROVIDER: S-EPMC5615133 | biostudies-literature | 2017 Sep-Oct

REPOSITORIES: biostudies-literature