Identification of potential therapeutic target genes and miRNAs for primary myelofibrosis with microarray analysis.

ABSTRACT: The aim of the present study was to identify potential therapeutic target genes and miRNAs for primary myelofibrosis (PMF). The dataset GSE53482 was downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs) of peripheral blood (PB) cluster of differentiation (CD)34⁺ cells from PMF patients (PB-PMF group) and peripheral blood CD34⁺ cells from healthy individuals (PB-control group) were analyzed using the Linear Models for Microarray Data package in R. The Kyoto Encyclopedia of Genes and Genomes was used for pathway enrichment analysis. MiRNA-gene joint enrichment analysis was performed by ENViz and a miRNAs-gene regulatory network was constructed. A total of 1,182 DEGs (773 upregulated and

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5615205 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature