Ontology highlight
ABSTRACT:
SUBMITTER: Adam E
PROVIDER: S-EPMC5615336 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Adam Etai E Kim Hye Na HN Gang Eun Ji EJ Schnair Caitlin C Lee Solomon S Lee Solah S Khazal Sajad S Kosoyan Osanna O Konopleva Marina M Parekh Chintan C Bhojwani Deepa D Wayne Alan S AS Abdel-Azim Hisham H Heisterkamp Nora N Kim Yong-Mi YM
Cancers 20170910 9
The quest continues for targeted therapies to reduce the morbidity of chemotherapy and to improve the response of resistant leukemia. Adhesion of acute lymphoblastic leukemia (ALL) cells to bone marrow stromal cells triggers intracellular signals that promote cell-adhesion-mediated drug resistance (CAM-DR). Idelalisib, an U.S. Food and Drug Administration (FDA)-approved PI3Kδ-specific inhibitor has been shown to be effective in CLL in down-regulating p-Akt and prolonging survival in combination ...[more]