Specific long non-coding RNAs response to occupational PAHs exposure in coke oven workers.

ABSTRACT: To explore whether the alteration of lncRNA expression is correlated with polycyclic aromatic hydrocarbons (PAHs) exposure and DNA damage, we examined PAHs external and internal exposure, DNA damage and lncRNAs (HOTAIR, MALAT1, TUG1 and GAS5) expression in peripheral blood lymphocytes (PBLCs) of 150 male coke oven workers and 60 non-PAHs exposure workers. We found the expression of HOTAIR, MALAT1, and TUG1 were enhanced in PBLCs of coke oven workers and positively correlated with the levels of external PAHs exposure (adjusted P_trend < 0.001 for HOTAIR and MALAT1, adjusted P_trend = 0.006 for TUG1). However, only HOTAIR and MALAT1 were significantly associated with the level of internal PAHs exposure (urinary 1-hydroxypyrene) with adjusted β = 0.298

SUBMITTER: Gao C 

PROVIDER: S-EPMC5615781 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature