A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance.

ABSTRACT: Lowered activity of the insulin/IGF signalling (IIS) network can ameliorate the effects of ageing in laboratory animals and, possibly, humans. Although transcriptome remodelling in long-lived IIS mutants has been extensively documented, the causal mechanisms contributing to extended lifespan, particularly in specific tissues, remain unclear. We have characterized the proteomes of four key insulin-sensitive tissues in a long-lived Drosophila IIS mutant and control, and detected 44% of the predicted proteome (6,085 proteins). Expression of ribosome-associated proteins in the fat body was reduced in the mutant, with a corresponding, tissue-specific reduction in translation. Expression of mitochondrial electron transport chain proteins in fat body was increased, leading to increased res

SUBMITTER: Tain LS 

PROVIDER: S-EPMC5615923 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature