Categorization of nano-structured titanium dioxide according to physicochemical characteristics and pulmonary toxicity.

ABSTRACT: A potentially useful means of predicting the pulmonary risk posed by new forms of nano-structured titanium dioxide (nano-TiO₂) is to use the associations between the physicochemical properties and pulmonary toxicity of characterized forms of TiO₂. In the present study, we conducted intratracheal administration studies in rats to clarify the associations between the physicochemical characteristics of seven characterized forms of TiO₂ and their acute or subacute pulmonary inflammatory toxicity. Examination of the associations between the physicochemical characteristics of the TiO₂ and the pulmonary inflammatory responses they induced revealed (1) that differences in the crystallinity or shape of the TiO₂ particles were not associated wit

SUBMITTER: Hashizume N 

PROVIDER: S-EPMC5615941 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature