Customized Tool for the Validation of Optical Coherence Tomography in Differentiation of Prostate Cancer.

ABSTRACT:

Objective

To design and demonstrate a customized tool to generate histologic sections of the prostate that directly correlate with needle-based optical coherence tomography pullback measurements.

Materials and methods

A customized tool was created to hold the prostatectomy specimens during optical coherence tomography measurements and formalin fixation. Using the tool, the prostate could be sliced into slices of 4 mm thickness through the optical coherence tomography measurement trajectory. In this way, whole-mount pathology slides were produced in exactly the same location as the optical coherence tomography measurements were performed. Full 3-dimensional optical coherence tomography pullbacks were fused with the histopathology slides using the 3-dimensional imaging softwar

SUBMITTER: Muller BG 

PROVIDER: S-EPMC5616116 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature