Unknown

Dataset Information

0

A modular design for minor groove binding and recognition of mixed base pair sequences of DNA.

ABSTRACT: The design and synthesis of compounds that target mixed, AT/GC, DNA sequences is described. The design concept connects two N-methyl-benzimidazole-thiophene single GC recognition units with a flexible linker that lets the compound fit the shape and twist of the DNA minor groove while covering a full turn of the double helix.

SUBMITTER: Guo P 

PROVIDER: S-EPMC5616130 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

A modular design for minor groove binding and recognition of mixed base pair sequences of DNA.

Guo Pu P   Paul Ananya A   Kumar Arvind A   Harika Narinder K NK   Wang Siming S   Farahat Abdelbasset A AA   Boykin David W DW   Wilson W David WD  

Chemical communications (Cambridge, England) 20170907 75

The design and synthesis of compounds that target mixed, AT/GC, DNA sequences is described. The design concept connects two N-methyl-benzimidazole-thiophene single GC recognition units with a flexible linker that lets the compound fit the shape and twist of the DNA minor groove while covering a full turn of the double helix. ...[more]

Similar Datasets

Unknown First Structure of a Designed Minor Groove Binding Heterocyclic Cation that Specifically Recognizes Mixed DNA Base Pair Sequences.
| S-EPMC6360951 | biostudies-literature
Unknown Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.
| S-EPMC3865524 | biostudies-literature
Unknown Imino proton NMR guides the reprogramming of A•T specific minor groove binders for mixed base pair recognition.
| S-EPMC4889958 | biostudies-literature
Unknown Engineered modular heterocyclic-diamidines for sequence-specific recognition of mixed AT/GC base pairs at the DNA minor groove.
| S-EPMC8672716 | biostudies-literature
Unknown Mixed up minor groove binders: Convincing A·T specific compounds to recognize a G·C base pair.
| S-EPMC4607563 | biostudies-literature
Unknown Imidazole-imidazole pair as a minor groove recognition motif for T:G mismatched base pairs.
| S-EPMC148692 | biostudies-other
Unknown Small Sequence-Sensitive Compounds for Specific Recognition of the G⋅C Base Pair in DNA Minor Groove.
| S-EPMC7265973 | biostudies-literature
Unknown Design and synthesis of heterocyclic cations for specific DNA recognition: from AT-rich to mixed-base-pair DNA sequences.
| S-EPMC3985508 | biostudies-literature
Unknown Specific molecular recognition of mixed nucleic acid sequences: an aromatic dication that binds in the DNA minor groove as a dimer.
| S-EPMC26607 | biostudies-literature
Unknown Subtle recognition of 14-base pair DNA sequences via threading polyintercalation.
| S-EPMC3369501 | biostudies-literature