Molecular classification of high grade endometrioid and clear cell ovarian cancer using TCGA gene expression signatures.

ABSTRACT:

Background

It is unclear whether the transcriptional subtypes of high grade serous ovarian cancer (HGSOC) apply to high grade clear cell (HGCCOC) or high grade endometrioid ovarian cancer (HGEOC). We aim to delineate transcriptional profiles of HGCCOCs and HGEOCs.

Methods

We used Agilent microarrays to determine gene expression profiles of 276 well annotated ovarian cancers (OCs) including 37 HGCCOCs and 66 HGEOCs. We excluded low grade OCs as these are known to be distinct molecular entities. We applied the prespecified TCGA and CLOVAR gene signatures using consensus non-negative matrix factorization (NMF).

Results

We confirm the presence of four TCGA transcriptional subtypes and their significant prognostic relevance (p<0.001) across all three histological subtypes

SUBMITTER: Winterhoff B 

PROVIDER: S-EPMC5616158 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature