Quantifiable predictive features define epitope-specific T cell receptor repertoires.

ABSTRACT: T cells are defined by a heterodimeric surface receptor, the T cell receptor (TCR), that mediates recognition of pathogen-associated epitopes through interactions with peptide and major histocompatibility complexes (pMHCs). TCRs are generated by genomic rearrangement of the germline TCR locus, a process termed V(D)J recombination, that has the potential to generate marked diversity of TCRs (estimated to range from 10¹⁵ (ref. 1) to as high as 10⁶¹ (ref. 2) possible receptors). Despite this potential diversity, TCRs from T cells that recognize the same pMHC epitope often share conserved sequence features, suggesting that it may be possible to predictively model epitope specificity. Here we report the in-depth characterization of ten epitope-specific TCR repertoires of C

SUBMITTER: Dash P 

PROVIDER: S-EPMC5616171 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature